Gene: [04^/PGM2] phosphoglucomutase 2;
|
COM |
Until 1984 the enzyme code was EC:2.7.5.1. |
|
FUN |
[1] Systematic name: alpha-D-glucose 1,6-phosphomutase.
Catalyzes reaction:
alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
[2] Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate. This bisphosphate is an intermediate in the reaction, being produced by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization. Also, more slowly, catalyses the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate." |
|
TIS |
The enzyme is predominantly expressed in red blood cells. |
|
FAG |
On the locations of genes coding for phosphoglucomutase isoforms, see GEM:01p31/PGM1." |
|
REF |
LOC,CYG,LIN "Bocian &: CCG, 25, (HGM5), 138, 1979 LOC,CYG,LIN "Francke U, Brown: CCG, 22, (HGM4), 401-405, 1978 FUN,PEP,FOG "Hopkinson, Harris: Ann Hum Genet, 30, 167-181, 1966 FUN,PEP,FOG "Hopkinson, Harris: Nature, 208, 410-412, 1965 LOC,CYG,LIN "McAlpine PJ &: CCG, 14, (HGM2), 368-369, 1975 FUN,PEP,FOG "Parrington &: Ann Hum Genet, 32, 27-34, 1968 LOC,CYG,LIN "Sparkes RS &: CCG, 22, (HGM4), 406-407, 1978a LOC,CYG,LIN "Sparkes RS &: Exp Cell Res, 111, 492-495, 1978b FUN,PEP,FOG "Spencer &: Nature, 204, 742-745, 1964 LOC,CYG,LIN "Wijnen LM &: Hum Genet, 37, 271-278, 1977 |
|
KEY |
carb, glyc |
|
CLA |
coding, basic |
|
LOC |
04 p14-q12 |
|
MIM |
MIM: 172000 |
|
EZN |
ENZYME: 5.4.2.2 |
